產(chǎn)品描述

生物素 Picolyl 疊氮 是一種先進(jìn)的生物素探針，它結(jié)合了銅螯合基序，可提高反應(yīng)位點 Cu（I） 的有效濃度，從而提高 CuAAC 反應(yīng)的效率，從而獲得更快、更具生物相容性的 CuAAC 標(biāo)記。據(jù)報道，與傳統(tǒng)疊氮化物相比，信號強(qiáng)度增加了 40 倍（參見精選參考文獻(xiàn)）。

Description

Biotin Picolyl Azide is an advanced biotin probe that incorporates a copper-chelating motif to raise the effective concentration of Cu(I) at the reaction site to boosted the efficiency of the CuAAC reaction resulting in a faster and more biocompatible CuAAC labeling. Up to 40-fold increase of signal intensity, compared to conventional azides was reported (see Selected References).

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化學(xué)結(jié)構(gòu)

精選文選

1.Wood, T. M., et al. (2021). Optimization of Metabolic Oligosaccharide Engineering with Ac4GalNAlk and Ac4GlcNAlk by an Engineered Pyrophosphorylase. ACS Chem. Biol.,

2. Banerjee, A.K.,et al. (2020). SARS-CoV-2 disrupts splicing, translation, and protein trafficking to suppress host defenses. Cells.,

3. Gaebler, A.,et al. (2016). A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins. J. Lipid. Res., 57, 1934-47.

4. Jiang, H., et al. (2014). Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry. Bioconjugate Chem.,, 25, 698-706.

5. Uttamapinant, C., et al. (2012). Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling. Angew. Chem. Int. Ed,., 51, 5852-56.